Real-World Weight Changes in People with Hiv-1 at Risk of Weight Gain (Female, Black or Hispanic) Switching from Integrase Strand Transfer Inhibitors

Journal of Comparative Effectiveness Research, 2023


Compare weight changes between people living with HIV-1 (PLWH) at high risk of weight gain (females, Blacks or Hispanics) switching from an integrase strand transfer inhibitor (INSTI) to a protease inhibitor (PI) or another INSTI.

Materials & methods

Mean weight changes from pre-switch to up-to-12 months post-switch were retrospectively compared between PLWH switching to a PI or INSTI.


356 PLWH were eligible. At 9- and 12-month post-switch, weight increases were observed for INSTI (weight: +1.55 kg and +1.59 kg), while decreases were observed for PI (-0.23 kg and -1.59 kg); differences between cohorts widened over time.


These data suggest that switching off an INSTI may be a management tool to mitigate or reverse weight gain.

View abstract


Donga P, Emond B, Shah A, Bookhart BK, Anderson D, Vermette-Laforme M, Rossi C, Lafeuille MH